If you use an ipad in a case then the homebutton is at your left side. With or without the screenlock all the apps open and can be used without turning the ipad 180.
If i i use the ipad with the homebutton at the left side, and open makeblock, it wil show up upside down and i have to turn the ipad 180. It is my only app that wont rotate on the ipad. Tested this on ipad air, ipad pro 9 and 12.9 inch.
The app works fine if you have the homebutton at the right side. Same thing on a iphone.